DR. MACRENE actives: High Performance skincare from $45, with free samples

Shopping at DR. MACRENE actives? See all current DR. MACRENE actives promo codes and deals, checked regularly.

DR. MACRENE actives is a premium skincare line from New York dermatologist Dr. Macrene Alexiades, who formulates the products herself. Her homepage introduces her as a dual board-certified dermatologist in the US and EU with medical and genetics degrees from Harvard, and the brand's pitch is plant actives in large numbers: it talks about 37 classes of plant actives, some grown on her own organic farm in New York State.

It suits people who are happy to spend more on a short routine of a few concentrated products, and anyone who likes to buy from a brand led by a practising dermatologist. Prices are firmly at the luxury end, so it's also worth knowing about the offers below before you buy.

The range is compact and sold under one "High Performance" name: a cleanser, a face serum, a face cream in regular and extra rich versions, an eye cream, a tinted moisturiser and a lip treatment called Lip Filler. There's also a Build Your Own Bundle option, a subscribe and save programme and a loyalty programme, all linked from the homepage.

What's worth a look

These six were among the best sellers on the brand's homepage, with the prices shown when we checked.

The High Performance Cleanser at $45 is the easiest way to try the brand. If you're after a moisturiser, the High Performance Face Cream is $225 and the Extra Rich version, for drier skin, is $265. The Lip Filler at $95 gets a mention in the press quotes on the homepage, which say it gives a subtle plumping effect without the stinging some lip treatments cause.

Current offers

• 15% off orders of $350 or more.
• Free shipping on orders of $300 or more.

When we checked, the homepage also said every order comes with two free samples, and orders of $350 or more got a complimentary Tinted Lip Filler in Berry (which it values at $65) while supplies last. Check our DR. MACRENE actives page before you buy, as we add new codes when we find them.

How to save more

• If you were going to buy two or three products anyway, aim for $350: that's where the 15% discount and the free Tinted Lip Filler both apply. A face cream and a serum together come to $340, so adding the cleanser takes you over.
• Use the free samples to try something new before buying the full size. You get two with every order.
• Look at Build Your Own Bundle and the subscribe and save option for products you use up regularly.

Products, prices and offers checked on the store's own website on 6 Nov 2026. Prices and stock can change.

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